News for Iran
|Cell phone effects: Testicular proteome modified|
|Iran||Created: 11 Sep 2014|
The controversy over the potential health effects of electromagnetic radiation associated with cell phones has been fuelled by new research originating in Iran - A team of scientists from Shiraz University has found that electromagnetic fields change the proteome of rat testes, with implications for fertility.
There has been conflicting evidence over the last decade on the harmful nature of these EMFs. For instance, some studies have suggested that they do not affect the brain whereas others have found the opposite. Most notably, a recent study from Greece revealed that 143 proteins in the mouse brain were affected, including some from the regions dealing with learning and memory. The same type of radiation is emitted by wireless transmitters and wireless computer equipment, so the effects might be more widespread than first anticipated.
Now, Masood Sepehrimanesh, Nasrin Kazemipour, Mehdi Saeb and Saeed Nazifi have turned their attention to the testis, comparing the protein expressions from animals exposed to an EMF with those that were not exposed. Their main focus was on proteins that were induced or completely inhibited, rather than those which underwent a partial change in expression.
Lab rats exposed to EMF
Over 30 days, ten rats were exposed daily to 900 MHz radiation for 1, 2 or 4 hours and ten others were sham exposed under the same conditions in the cage. After this period, they were sacrificed and the proteins extracted from the testes.
The protein components in the extracts were separated by 2D SDS-PAGE under a protocol designed to minimise technical variations. Each testis sample was analysed in triplicate and all of the samples were prepared at the same time by a single technician using the same apparatus.
The separated proteins on the gel were visualised with a silver stain and those that were present only in the irradiated group or the sham group were marked as candidates for identification by mass spectrometry following digestion with trypsin.
Protein oxidation induced
The total number of protein spots on the gels ranged from 365 to 439 but there was little difference between the protein patterns for all three exposure groups. The overall protein concentrations and weights of the testes were not affected by the EMF treatment but there were some differences in individual proteins.
Significantly, 18 proteins were found only in the exposed group and 16 in the sham exposed group. They were not a result of thermal damage to the testes because the temperatures were maintained at 23°C during the whole program. The strongest and best separated spots, numbering 7 and 6 in the exposed and sham exposed groups, respectively, were analysed.
One of the proteins that disappeared following irradiation is Cu-Zn superoxide dismutase which offers major protection against oxygen toxicity in the testis. Its absence was attributed to the lack of viable spermatogonia, immature stem cells that form spermatocytes, where it is normally found in large quantities. If validated in further research, this effect alone is a serious consequence of EMFs.
The appearance of type II peroxiredoxin 1 in the testis after exposure to the EMF was due to over-oxidation of its cysteine residues. The occurrence of oxidative stress was supported by the appearance of heat shock proteins, possibly induced to combat the formation of free radicals, and the loss of valosin-containing protein due to the oxidative S-thiolation of cysteine residues.
Other affected proteins were related to metabolism and cytoskeletal processes within the testis. So, several different processes within the testis appear to be affected by the impact of EMFs.
The research team acknowledge that their findings will have to be confirmed by complementary studies using other methods like Western blotting and immunohistochemical procedures. However, if the protein alterations can be repeated, then exposure to EMFs from cell phones and wifi equipment will have to be reconsidered by national and international health organisations as they could have a bearing on male fertility.
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|Source: Spectroscopy Now, Steve Down, 01 Sep 2014|
|Mobile-phone radiation accelerates mercury release from dental amalgam fillings|
|Iran||Created: 3 Oct 2008|
A new important clue in the connection between mobile-phone radiation and the increase of electrohypersensitivity, autism, allergies, alzheimers, parkinsons comes from researchers at the Department of Medical Physics, Shiraz University in Iran.
The researchers have discovered that exposure to mobile-phone radiation or MRI-scan magnetic field significantly accelerates the release of mercury from dental fillings and into the body.
In the 1st phase of this study, thirty patients were investigated. Five milliliter stimulated saliva was collected just before and after MRI. The magnetic flux density was 0.23 T and the duration of exposure of patients to magnetic field was 30 minutes.
In the 2nd phase, fourteen female healthy University students who had not used mobile phones before the study and did not have any previous amalgam restorations were investigated.
Dental amalgam restoration was performed for all 14 students. Their urine samples were collected before amalgam restoration and at days 1, 2, 3 and 4 after restoration.
The mean +/- SD saliva Hg concentrations of the patients before and after MRI were 8.6 +/- 3.0 and 11.3 +/- 5.3 microg L(-1), respectively (p < 0.01).
A statistical significant (p < 0.05) higher concentration was observed in the students used mobile phone.
The mean +/- SE urinary Hg concentrations of the students who used mobile phones were 2.43 +/- 0.25, 2.71 +/- 0.27, 3.79 +/- 0.25, 4.8 +/- 0.27 and 4.5 +/- 0.32 microg L(-1) before the amalgam restoration and at days 1, 2, 3 and 4, respectively.
Whereas the respective Hg concentrations in the controls, were 2.07 +/- 0.22, 2.34 +/- 0.30, 2.51 +/- 0.25, 2.66 +/- 0.24 and 2.76 +/- 0.32 microg L(-1).
It appears that MRI and microwave radiation emitted from mobile phones significantly release mercury from dental amalgam restoration.
Further research is needed to clarify whether other common sources of electromagnetic field exposure may cause alterations in dental amalgam and accelerate the release of mercury.
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|Source: PubMed, Mortazavi SM, Daiee E, Yazdi A, Khiabani K, Kavousi A, Vazirinejad R, Behnejad B, Ghasemi M, Mood MB, Apr 2008|
|Cancer link to heavy mobile use|
|Iran||Created: 25 Feb 2008|
Heavy mobile phone use may be linked to an increased risk of cancer of the salivary gland, a study suggests.
Researchers looked at 500 people who had developed the condition and compared their mobile phone usage with 1,300 healthy controls.
Those who had used the phone against one side of the head for several hours a day were 50% more likely to have developed a salivary gland tumor.
The research appeared in The American Journal of Epidemiology.
Numerous studies have focused on the risk of tumors among those who use mobile phones, and overwhelmingly found no increased cancer risk.
But researchers say these have tended to focus on brain tumors, and often did not include long-term users.
Cancer of the salivary gland is a very rare condition. Of the 230,000 cases of cancer diagnosed in the UK for instance annually, only 550 relate to this area.
One of the key findings of the study was that heavy users in rural areas had an even higher risk that those in cities, due, the team suggested, to the fact that mobile phones in areas without strong signals need to emit more radiation to work properly.
But Dr. Siegal Sadetzki, who led the research, stressed one study was not enough to prove a link, and that further research was needed.
Nonetheless, until more evidence became available, a ""precautionary"" approach was best, she said, particularly when it comes to children's use of mobile phones.
Despite these latest findings, the largest and longest-running investigation ever to be carried out into mobile phone usage found no increased risk of any sort of cancer.
It followed 420,000 people in Denmark, some of whom had been using a mobile phone for as long as ten years.
There was in fact a lower incidence of cancer than expected in a group of that size, suggesting mobile phones had no impact on the development of tumors.
Last year, the UK's Mobile Telecommunications and Health Research Program said that while the evidence so far was "reassuring", there was still a need for studies to examine the very long-term impact, and to look at the effect in children.
Ed Yong, of Cancer Research UK, said: ""Mobile phones are a relatively recent invention and new research into any possible health risks is welcome.
"However, it's important to remember that the vast majority of studies so far have found that mobile phones do not increase the risk of any type of cancer."
|Click here to view the source article.|
|Source: Tehran Times,|