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www.mast-victims.org forum / Health / Lack of MELANIN and radaiation induced hearing loss.
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plopplop
# Posted: 16 May 2018 10:01
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Does all-day and long-term exposure to radiofrequency radiation emitted from Wi-Fi affect hearing?

https://www.tandfonline.com/doi/full/10.1080/13102818.2017.1373033

plopplop
# Posted: 30 May 2018 21:37
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583885/

Melanin is very amasing stuff and links into the ONOO explanation of EHS. We eat pesticided food that destroys melanin. Fungicides mostly on rice. Is this adequately tested for on entry to the EU?

I find the underinvestment on accessible research into melanin very disturbing as it is our primary radiation defense. There appears to be absolutely no studies on its capacity to short out micro waves at all. WHY?

Considering chronobiological aspects of melatonin, it regulates the circadian day-night-rhythm and seasonal bio-rhythms,3,4 and independent of that, melatonin has been shown in the mammalian system to modulate immune defense responses,5,6 body weight and reproduction4 and to exert tumor growth-inhibitory and anti-jet lag effects.7-10 Additionally, melatonin serves as a direct, receptor-independent potent antioxidant,11-13 a chemotoxicity-reducing agent,14-16 a putative general anti-aging substance17,18 and an anti-cancer agent.19

For decades, investigations concerning occurrence of melatonin in different body compartments revealed that significantly high concentrations are found in the bile fluid,20 bone marrow,21 cerebrospinal fluid,22 ovary,23 eye,24 lymphocytes5 or skin25 and is differentially distributed in subcellular organelles.21,26-28 It was reported that melatonin levels in organs mentioned above may be 10- to 1000-fold higher than in the plasma.27,28 High concentrations of melatonin across different organs suggest an ubiquitous, biologically highly relevant existence of tissue-specific, local melatoninergic systems which have the biological role of counteracting specific tissue-related regional stressors exactly at the place where they occur.20,21,25,27 In the skin, a melatoninergic antioxidative system (MAS) has been recently discovered in a highly differentiated manner regulating skin homeostasis and—very importantly—having the potential to prevent the harmful consequences of UV solar skin damage, i.e., skin aging and skin cancer.25,29,30
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Melatonin as an Activity Enhancer of Antioxidative Enzymes

Melatonin was discovered to be a free radical scavenger two decades ago.11 However, the data documenting its ability to overcome oxidative stress has accumulated at a rapid pace and is now abundant.44-46 The efficacy of melatonin in functioning in this capacity relates to its direct free radical scavenging actions.44 The chemical formula of melatonin allows to interact with various forms of free radicals such as H2O2, •OH, singlet oxygen (1O2), superoxide anion (•O2−), peroxynitrite anion (ONOO−) and peroxyl radical (LOO•).12 It should be noted that melatonin's antioxidant mechanism of action implies a free radical scavengers cascade in case of UV irradiation. Metabolites of melatonin degradation are formed such as N1-acetyl-5-methoxykynuramine (AMK) or N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), the main photoproducts and simultaneously potent antioxidants.25,47 Moreover, investigations using cell-free melatonin containing systems exposed to UV radiation (UVB: 60%, UVA: 30%) revealed four metabolites identified by HPLC and LC-MS: 2-OH-melatonin, 4-OH-melatonin, 6-OH-melatonin and AFMK.25 Since these metabolites are partly or fully potent antioxidants, this may suggests that melatonin metabolites, unlike classic antioxidants, do not induce prooxidant reactions.

Melatonin acts as a potent antioxidative agent also by indirect effects through enhancing activity of antioxidative enzymes.29 Of note, not only enzyme activity, but also gene transcription of antioxidant enzymes such as manganese superoxide dismutase (Mn-SOD), copper-zinc superoxide dismutase (Cu/Zn-SOD), GPx and gamma-glutamylcysteine synthetase (-GCS), the rate-limiting enzyme of glutathione (GSH) synthesis,48-50 was upregulated by melatonin during porphyrin-induced cell damage in rat brain cortex and in neuronal cell lines.48 This prolonged elevation suggests a possible involvement of membrane and/or nuclear melatonin receptor activation with signal transduction on transcriptional mRNA level to modify the regulation of antioxidant enzymes by melatonin following outer signals to stress.51,52

Currently, there are some proposals that melatonin-mediated expression of antioxidant enzymes is dependent of signal transduction pathways related to membrane, cytosolic and nuclear receptors,53 but this hypothesis still needs to be elucidated.

plopplop
# Posted: 5 Jun 2018 10:00
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"There are very few examples of natural organic semiconductors and melanin was thought to be the very first example, demonstrated to be such in the early 70s," said Professor Meredith.

Co-author Associate Professor Powell said that in semiconductors, such as those found in computers and mobile phones, electrons carry the electrical current. However, in biological systems, such as brains and muscles, ions carry the current.

"We've now found that in melanin, both electrons and ions play important roles," he said.

The study – published recently in Proceedings of the National Academy of Sciences – points to a new way of interfacing conventional electronics to biological systems using a combination of ion-and-electron conducting biomaterials such as melanin.

"Melanin is able to 'talk' to both electronic and ionic control circuitry and hence can provide that connection role," said Professor Meredith about the study's finding, the culmination of ten years of research and experiments.

"There are very few materials that meet these compatible bioelectronic requirements, and an insight into melanin's important biological functions and properties has been really crucial in this study."

In recent years, the electronics industry has been driven to develop materials and components that are cheaper and more environmentally friendly.

"There is a realisation that in many such applications, we should move on from the relatively more expensive inorganic semiconductors. We need cheaper, safer electronic materials with greener credentials," said Professor Meredith.

"Organic conductors and semiconductors are widely viewed has having enormous potential in this regard, and in the area of medical sensors and devices, biocompatibility will be a key requirement."

The team is currently working on creating ion-based electrical devices using melanin, with a view to ultimately connect them to actual biological systems.

"A critical area that one could foresee for bioelectronics is stimulating or repairing signal-carrying pathways in tissues such as muscle or brain," said Professor Meredith.

Other researchers in the study are Professor Ian Gentle, Professor Graeme Hanson, Dr Bernie Mostert (currently at Lancaster University and central figure in the research) -- all from The University of Queensland, as well as researchers from the United Kingdom and Poland.



Read more at: https://phys.org/news/2012-06-melanin-bio-friendly-electronics.html#jCp

plopplop
# Posted: 5 Jun 2018 10:53
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Abstract https://www.semanticscholar.org/paper/Charge-Transport-in-Melanin%2C-a-Disordered-Con ductor-Giacomantonio/19ee7fa67f3c514af1d0331389747fea518ebf74

Melanins are biological macromolecules with many roles in the biosphere including as pigments and photoprotects. They have been shown to possess several interesting physical and chemical properties. However, these properties are, in general, poorly understood. This thesis presents a systematic investigation into charge transport physics in melanin. Charge transport-related properties in solid state melanin have been shown to be highly dependent on hydration but these dependencies have been poorly characterised. In this thesis, the relationship between the conductivity of solid-state melanin and hydration is investigated and, for the first time, tied to theoretical predictions on the effects of water on conductivity and interpreted in terms of specific charge transport mechanisms. It is suggested that melanin is a mixed conductor and that the dominant charge carriers change from electrons to protons as hydration increases. Thermogravimetic analysis of melanin suggests that melanin may contain two fractions of water—a strongly bound and a weakly bound fraction. Scanning electron microscopy of two different types of synthetic melanin shows a similar layered structure in both samples. Finally, an attempt at measurement of the proton mobility is outlined. (Less)

plopplop
# Posted: 5 Jun 2018 19:06
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https://en.wikipedia.org/wiki/Melanin-concentrating_hormone#Tissue_distribution

Melanin-concentrating hormone (MCH) is a cyclic 19-amino acid orexigenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish, where it controls skin pigmentation.[1] In mammals it is involved in the regulation of feeding behavior, mood, sleep-wake cycle and energy balance.[

Activation and deactivation

MCH neurons depolarize in response to high glucose concentrations.[5] This mechanism seems to be related to glucose being used as a reactant to form ATP, which also causes MCH neurons to depolarize.[5] The neurotransmitter, glutamate, also causes MCH neurons to depolarize, while another neurotransmitter, GABA, causes MCH neurons to hyperpolarize.[5] Orexin also depolarizes MCH neurons.[5] MCH neurons seems to have an inhibitory response to MCH, but does not cause the neurons to become hyperpolarized.[5] Norepinephrine has an inhibitory effect on MCH neurons as does acetylcholine.[5] MCH neurons hyperpolarize in response to serotonin.[5] Cannabinoids have an excitatory effect on MCH neurons.[5]


Does this not mean that EMR will effect this essential regulator? Hence meds and self meds used to treat EHS.

plopplop
# Posted: 5 Jun 2018 19:20
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What happens if I have too little melanocyte-stimulating hormone?

http://www.yourhormones.info/hormones/melanocyte-stimulating-hormone/

A deficiency in melanocyte-stimulating hormone results in a lack of skin pigmentation and subsequent loss of natural protection from UV rays of the sun. In secondary adrenal insufficiency, damage to the pituitary gland prevents release of adrenocorticotropic hormone and melanocyte-stimulating hormone and there is reduced pigmentation of the skin. Melanocyte-stimulating hormone deficiency can cause increased inflammation, pain, and sleeping problems, as well as a reduction in the levels of anti-diuretic hormone, which causes thirst and frequent urination. Melanocyte-stimulating hormone deficiency may also result in increased food intake and obesity.

plopplop
# Posted: 18 Oct 2018 20:52
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https://www.ncbi.nlm.nih.gov/pubmed/3070525

plopplop
# Posted: 18 Oct 2018 20:53
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The presence of melanin in the inner ear was established more than a century ago, but the exact biological function of the pigment in the labyrinth has yet to be determined.

plopplop
# Posted: 23 Oct 2018 09:14
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Exposure to non-ionizing electromagnetic fields emitted from mobile phones induced DNA damage in human ear canal hair follicle cells

https://www.tandfonline.com/doi/abs/10.1080/15368378.2018.1463246?fbclid=IwAR2SNkfhJB fMQlalp0xExdgicSaONzm0cUK-fzi3QR281zJ876Z_TasW0k0&

emfcaveman
# Posted: 23 Oct 2018 22:04
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plopplop I'm sorry to hijack this thread. Your posts are very interesting, and in one post you explained that you use a very low-powered low-EMF computer. Could you explain what parts you used or how you've built it? I'd like to try a build something similar myself. Perhaps make a new post if needed?

plopplop
# Posted: 28 Oct 2018 09:40
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Look for a fanless SSD "Slim Client" from China from Aliexpress, and run on a 12vDC linear power supply and 12vDC low wattage monitor ( less than 10 watts). Use a rollerball mouse and use ferrite chokes on all cables. This works and there is nearly no rads. You wont get better. Remember low watts is low rads. I am sure I listed all this on es-forum. I have tried every thing and this is the best system I have found.

emfcaveman
# Posted: 29 Oct 2018 15:58
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Thanks plop. I found some on Aliexpress now.
Have you found a good low-EMF keyboard also?

Henrik
Admin
# Posted: 30 Oct 2018 09:54
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emfcaveman,

"Have you found a good low-EMF keyboard also?"

Suggestions to buy:
https://emfacademy.com/low-emf-keyboard-a-buyers-guide/

DIY:
https://www.lowemfoffice.com/keyboard_shielding_steps/index.htm

plopplop
# Posted: 17 Nov 2018 11:08
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Brill stuff but I really react badly to AM radio coming out of these keyboard and I am not sure how well he addresses this. Mice are easy with a rollerball. By low EMF do they just mean low wattage? Have you compared one of these with an ordinary KB using a radio? I think the lowest wattage ones are for external tablets but they tend to be wireless now and not wired. Have you tried a USB current meter on any of these? I have a KB covered with ali foil and conductive paint but it really does not stop AM radio coming out as nothing much does. I am sure that a fiber optic KB could produce
zero rads if some one really wanted to.

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